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The Biology of Aging: Reversing the Clock in Your Cells

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Can we actually reprogram our cells to reverse aging? From Harvard's David Sinclair to the Salk Institute's breakthrough research, this episode unpacks the 12 hallmarks of aging and reveals practical strategies-beyond supplements-that are scientifically proven to add healthy years to your life.

The Biology of Aging: Reversing the Clock in Your Cells
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How This Personalized Podcast Was Made

This podcast was created using BeFreed’s AI, based on selected books, the creator’s learning goals, and their preferred tone.

Hallmarks of aging: An expanding universe
link
https://doi.org/10.1016/j.cell.2022.11.001
Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
link
https://www.hubermanlab.com/episode/dr-peter-attia-exercise-nutrition-hormones-for-vitality-and-longevity
Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results
link
https://www.aging-us.com/article/206235
The science of cells that never get old
link
https://www.ted.com/talks/elizabeth_blackburn_the_science_of_cells_that_never_get_old
The Telomere Effect
link
https://www.befreed.ai/book/the-telomere-effect-by-elizabeth-blackburn
Outlive
link
https://www.befreed.ai/book/outlive-by-peter-attia
A roadmap to end aging
link
https://www.ted.com/speakers/aubrey_de_grey
#201 – Deep dive back into Zone 2 (Pt. 2)
link
https://peterattiamd.com/inigosanmillan2/
Association of Cardiorespiratory Fitness With Long‑term Mortality Among Adults Undergoing Exercise Treadmill Testing
link
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2707428
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
link
https://pmc.ncbi.nlm.nih.gov/articles/PMC10737863/
Calorie Restriction May Not Extend Life
link
https://www.nih.gov/news-events/nih-research-matters/calorie-restriction-may-not-extend-life
Caloric restriction delays disease onset and mortality in rhesus monkeys
link
https://pubmed.ncbi.nlm.nih.gov/19590001/
The Longevity Diet
link
https://www.goodreads.com/book/show/50772571-the-longevity-diet
Reprogramming to recover youthful epigenetic information and restore vision
link
https://pubmed.ncbi.nlm.nih.gov/33268865/
In vivo amelioration of age‑associated hallmarks by partial reprogramming
link
https://colab.ws/articles/10.1016/j.cell.2016.11.052
#771 – Dr Peter Attia – Scientifically Proven Ways To Build Muscle & Boost Longevity
link
https://www.tapesearch.com/episode/771-dr-peter-attia-scientifically-proven-ways-to-build-muscle-boost-longevity/TYUee2SrAEXkc4vFNucENG
Ageless: The New Science of Getting Older Without Getting Old
link
https://www.befreed.ai/book/ageless-by-andrew-steele
Chronic nicotinamide riboside supplementation elevates NAD+ in healthy middle‑aged and older adults
link
https://pubmed.ncbi.nlm.nih.gov/29599478/
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
link
https://pubmed.ncbi.nlm.nih.gov/33888596/
Dr. David Sinclair: The Biology of Slowing & Reversing Aging
link
https://www.hubermanlab.com/episode/dr-david-sinclair-the-biology-of-slowing-and-reversing-aging
Life Biosciences Presents Groundbreaking Data at ARVO: Restoration of Visual Function in Nonhuman Primates
link
https://www.lifebiosciences.com/life-biosciences-presents-groundbreaking-data-at-arvo-demonstrating-restoration-of-visual-function-in-nonhuman-primates/
Lifespan: Why We Age—and Why We Don’t Have To
link
https://www.goodreads.com/book/show/43723901-lifespan
Senolytics decrease senescent cells in humans: Dasatinib plus quercetin in diabetic kidney disease
link
https://pubmed.ncbi.nlm.nih.gov/31542391/
The TAME Trial (Targeting Aging with Metformin)
link
https://www.afar.org/tame-trial
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: randomized pilot trial
link
https://doi.org/10.1016/j.ebiom.2023.104481
Relationship of Sleep Duration With All‑Cause Mortality and Cardiovascular Events: Dose‑Response Meta‑analysis
link
https://www.ahajournals.org/doi/10.1161/JAHA.117.005947
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Input question

Can you explain how we might be able to slow down or reverse the aging process?

Podcast Style
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"Perfect balance between learning and entertainment. Finished ‘Thinking, Fast and Slow’ on my commute this week."

@Raaaaaachelw
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"Crazy how much I learned while walking the dog. BeFreed = small habits → big gains."

@Matt, YC alum
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108

"Reading used to feel like a chore. Now it’s just part of my lifestyle."

@Erin, Investment Banking Associate , NYC
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254
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17

"Feels effortless compared to reading. I’ve finished 6 books this month already."

@djmikemoore
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"BeFreed turned my guilty doomscrolling into something that feels productive and inspiring."

@Pitiful
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"BeFreed turned my commute into learning time. 20-min podcasts are perfect for finishing books I never had time for."

@SofiaP
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"BeFreed replaced my podcast queue. Imagine Spotify for books — that’s it. 🙌"

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"It is great for me to learn something from the book without reading it."

@OojasSalunke
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"The themed book list podcasts help me connect ideas across authors—like a guided audio journey."

@Leo, Law Student, UPenn
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483

"Makes me feel smarter every time before going to work"

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"I never knew where to start with nonfiction—BeFreed’s book lists turned into podcasts gave me a clear path."

@Chloe, Solo founder, LA
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117

"Perfect balance between learning and entertainment. Finished ‘Thinking, Fast and Slow’ on my commute this week."

@Raaaaaachelw
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"Crazy how much I learned while walking the dog. BeFreed = small habits → big gains."

@Matt, YC alum
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12
likes
108

"Reading used to feel like a chore. Now it’s just part of my lifestyle."

@Erin, Investment Banking Associate , NYC
platform
comments
254
likes
17

"Feels effortless compared to reading. I’ve finished 6 books this month already."

@djmikemoore
platform
star
star
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star
star

"BeFreed turned my guilty doomscrolling into something that feels productive and inspiring."

@Pitiful
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4.5K

"BeFreed turned my commute into learning time. 20-min podcasts are perfect for finishing books I never had time for."

@SofiaP
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@Jaded_Falcon
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"It is great for me to learn something from the book without reading it."

@OojasSalunke
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"The themed book list podcasts help me connect ideas across authors—like a guided audio journey."

@Leo, Law Student, UPenn
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483

"Makes me feel smarter every time before going to work"

@Cashflowbubu
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