
Why do we get sick? Nesse and Williams revolutionized medicine by applying Darwin's principles to illness, revealing that many symptoms are actually evolutionary adaptations. This groundbreaking text challenges conventional wisdom - fever, morning sickness, and anxiety aren't malfunctions but ancient protective mechanisms still shaping human health today.
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Have you ever wondered why, despite millions of years of evolution, our bodies still break down? Why we suffer from cancer, allergies, and infections despite being marvels of biological engineering? The answer lies in viewing disease through an evolutionary lens. Rather than seeing illnesses as simple mechanical failures, they're often consequences of our evolutionary history-compromises, trade-offs, and adaptations that once benefited our ancestors but may harm us in modern environments. This perspective, pioneered by Randolph Nesse and George Williams, has transformed medicine's understanding of why we get sick. Our bodies simultaneously showcase engineering brilliance and apparent design flaws. Our bones are stronger than steel yet lighter than aluminum. Our kidneys filter blood with remarkable precision. Yet we have airways that cross food passages creating choking hazards, widespread nearsightedness, and arteries prone to cholesterol buildup. Understanding this paradox requires distinguishing between proximate causes (how the body works) and evolutionary causes (why natural selection hasn't eliminated harmful traits). Both explanations are necessary for a complete picture of disease.
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