
Isaacson reveals how da Vinci's insatiable curiosity united art and science, creating masterpieces like the Mona Lisa. Bill Gates praised it as "exceptional" for showing why Leonardo's passionate observation and imaginative thinking still inspire our approach to innovation today.
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Leonardo da Vinci began a letter to the ruler of Milan listing his engineering and architectural qualifications. Only in the eleventh paragraph did he casually mention: "Likewise in painting, I can do everything possible." This understated claim came from the man who would create the Mona Lisa and The Last Supper. Born illegitimate in 1452 Tuscany, Leonardo's exclusion from his father's notary profession became a blessing, freeing him to pursue boundless curiosity. His childhood in the countryside developed his observational skills, studying how light played across landscapes and examining nature with uncommon intensity. His most vivid memory involved discovering a cave near Florence. "Suddenly there arose in me two contrary emotions, fear and desire," he wrote-a tension between fear and curiosity that defined his approach to knowledge. Unlike educated contemporaries, Leonardo received no formal classical education, instead learning practical mathematics. This lack of Latin learning became both limitation and liberation, allowing him to develop an empirical method free from medieval dogmas. His left-handedness-evident in his mirror writing-further marked him as different. At fourteen, he began apprenticing with Andrea del Verrocchio, Florence's premier artist-engineer, learning not just painting but engineering principles and anatomical study.