When Your Immune System Hijacks Sleep

44 min

Lena and Eli dissect episodic post-viral insomnia as immune signaling gone rogue, exploring how inflammation can paradoxically wire you up instead of knocking you out. They integrate cutting-edge research to reveal why your nervous system sometimes holds sleep hostage-and how to negotiate its releas

When Your Immune System Hijacks Sleep

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このポッドキャストはBeFreedのAIを使用して、選択された本、作成者の学習目標、好みのスタイルに基づいて作成されました。

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episodic post-viral or autoimmune insomnia as a transient governance failure where immune signaling directly modulates brain states, using The Inflamed Mind by Edward Bullmore to argue that inflammatory signals can misfire and generate maladaptive neural outputs producing hyperarousal rather than fatigue, Why We Sleep by Matthew Walker to frame sleep as a master regulator of immune, metabolic, and autonomic balance, The Polyvagal Theory by Stephen Porges to explain how autonomic state determines access to restorative physiology and why sleep is suspended when immune signaling pushes the system into a defensive hierarchy, and Sick Souls, Healthy Minds by John J. Ratey to describe psychiatric symptoms as emergent network instabilities reflecting reversible state shifts. The episode will explore how Bullmore and Walker diverge on failure modes, with Walker predicting immune activation should increase sleep drive while Bullmore allows for signal inversion, examine how Porges explains the on-off quality that Walker cannot, and argue that episodic immune-linked insomnia demonstrates that wake-promoting systems can temporarily outrank sleep need entirely, making the correct abstraction state arbitration failure rather than deprivation. It will present a layered treatment logic matching interventions to the failing layer, including immune modulation to shorten episodes, autonomic downshifting as highest leverage during episodes, neuroendocrine timing to prevent night-specific failure, and behavioral containment for damage control. The episode will outline an integrated treatment model prioritizing immune stability and autonomic resilience between episodes and sympathetic dampening during episodes, present the decision rule that sudden insomnia resolving cleanly should treat state while drifting persistent insomnia should treat learning and behavior, and conclude with the novel synthesis that this phenotype is a threshold disorder best treated by addressing the veto rather than the sleep drive.

ポッドキャストスタイル
Lenaplay
Eliplay

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"Reading used to feel like a chore. Now it’s just part of my lifestyle."

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"Feels effortless compared to reading. I’ve finished 6 books this month already."

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"BeFreed turned my guilty doomscrolling into something that feels productive and inspiring."

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"The themed book list podcasts help me connect ideas across authors—like a guided audio journey."

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