
Demystifying the science that could save millions, Jonathan Slack's "Stem Cells" cuts through misinformation about revolutionary medical treatments. While private clinics peddle false promises, this developmental biologist reveals which therapies might actually cure Parkinson's, diabetes, and spinal trauma - and which remain science fiction.
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Imagine having a magic seed that could grow into any plant you needed-an oak tree, a rose bush, or wheat for bread. Stem cells are essentially the biological equivalent of this magic seed. These extraordinary cells possess two unique abilities that set them apart from the other 210 cell types in your body: they can reproduce themselves indefinitely (self-renewal) and generate specialized cells for specific functions (potency). This remarkable dual capacity makes them both a reservoir of new cells and a factory for specialized tissue components. Your skin provides a perfect example of stem cells in action. That smooth surface you see in the mirror completely replaces itself every few weeks. Deep in the basal layer of your epidermis, stem cells divide asymmetrically-one daughter cell remains a stem cell while the other begins transforming as it moves upward, producing keratin proteins before eventually dying and shedding from the surface. This happens continuously, with 30,000-40,000 cells shed hourly. What truly makes stem cells special is their microenvironment or "niche"-a specialized ecosystem supporting their function. In skin, stem cells associate with dermal papillae; in intestines, they nestle alongside Paneth cells; in bone marrow, they reside near blood vessels. These niches provide crucial signals maintaining "stemness" through complex molecular pathways involving genes like Oct4, Sox2, and Nanog.
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Cree par des anciens de Columbia University a San Francisco
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Cree par des anciens de Columbia University a San Francisco

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